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Take the 4-10 fragment of adrenocorticotropic hormone. Add a Pro-Gly-Pro tail for metabolic stability. The result is Semax — a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences that retains neurotrophic activity from the parent hormone while completely shedding its adrenal steroidogenic effects. Over 100 published papers have examined this compound in the context of neurotrophic factor expression, neuropeptide signaling, and CNS pathway modulation.
SEQUENCEMet-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-10 + PGP)AMINO ACIDS7MOLECULAR FORMULAC39H63N11O10MOLECULAR WEIGHT813.97 g/molCAS NUMBER80714-61-0FORMLyophilized powderQUANTITY5mg per vial
Research has documented Semax’s influence on BDNF, NGF, and GDNF expression in neuronal cultures. The interesting part is what it does not do: unlike the full ACTH molecule, the 4-10 fragment does not drive adrenal steroid production. The neurotrophic activity and steroidogenic activity occupy different regions of the parent peptide, and Semax retains only the former.
Published studies have examined dopaminergic and serotonergic system modulation, oxidative stress markers in neuronal models, and the pharmacokinetic properties of the Pro-Gly-Pro stability extension — a design shared with the related peptide Selank (tuftsin + PGP).
Selank 5mg — Both share the PGP stabilization motif but derive from different parent sequences.
Third-party tested with mass spectrometry identity confirmation. Batch-specific COAs available.
Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days
For laboratory research use only. Not for human or veterinary use.
Take the 4-10 fragment of adrenocorticotropic hormone. Add a Pro-Gly-Pro tail for metabolic stability. The result is Semax — a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences that retains neurotrophic activity from the parent hormone while completely shedding its adrenal steroidogenic effects. Over 100 published papers have examined this compound in the context of neurotrophic factor expression, neuropeptide signaling, and CNS pathway modulation.
SEQUENCEMet-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-10 + PGP)AMINO ACIDS7MOLECULAR FORMULAC39H63N11O10MOLECULAR WEIGHT813.97 g/molCAS NUMBER80714-61-0FORMLyophilized powderQUANTITY5mg per vial
Research has documented Semax’s influence on BDNF, NGF, and GDNF expression in neuronal cultures. The interesting part is what it does not do: unlike the full ACTH molecule, the 4-10 fragment does not drive adrenal steroid production. The neurotrophic activity and steroidogenic activity occupy different regions of the parent peptide, and Semax retains only the former.
Published studies have examined dopaminergic and serotonergic system modulation, oxidative stress markers in neuronal models, and the pharmacokinetic properties of the Pro-Gly-Pro stability extension — a design shared with the related peptide Selank (tuftsin + PGP).
Selank 5mg — Both share the PGP stabilization motif but derive from different parent sequences.
Third-party tested with mass spectrometry identity confirmation. Batch-specific COAs available.
Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days
For laboratory research use only. Not for human or veterinary use.